- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Calculated MW||21997 Da|
|Antigen Region||6-37 aa|
|Other Names||Calcipressin-2, Down syndrome candidate region 1-like 1, Myocyte-enriched calcineurin-interacting protein 2, MCIP2, Regulator of calcineurin 2, Thyroid hormone-responsive protein ZAKI-4, RCAN2, DSCR1L1, ZAKI4|
|Target/Specificity||This DSCR1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-37 amino acids from the N-terminal region of human DSCR1L1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DSCR1L1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.|
|Tissue Location||Expressed in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas|
Provided below are standard protocols that you may find useful for product applications.
DSCR1L1 inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. This protein may play a role during central nervous system development. Expression is detected in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas. Expression of both transcripts is upregulated by physiologic concentrations of the thyroid hormone triiodothyroxine.
Rothermel, B., et al., J. Biol. Chem. 275(12):8719-8725 (2000).
Fuentes, J.J., et al., Hum. Mol. Genet. 9(11):1681-1690 (2000).
Strippoli, P., et al., Genomics 64(3):252-263 (2000).
Miyazaki, T., et al., J. Biol. Chem. 271(24):14567-14571 (1996).
Cao, X., et al., Biochem. J. 367 (PT 2), 459-466 (2002) (): ().
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