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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DSCR1L1 Antibody (N-term)   

DSCR1L1 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DSCR1L1 Antibody (N-term) AP6316b
    DSCR1L1 Antibody (Q21) (Cat. #AP6316b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the DSCR1L1 antibody detected the DSCR1L1 protein (arrow).
  • WB - DSCR1L1 Antibody (N-term) AP6316b
    DSCR1L1 Antibody (Q21) (Cat. #AP6316b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the DSCR1L1 antibody detected the DSCR1L1 protein (arrow).
  • IHC-P - DSCR1L1 Antibody (N-term) AP6316b
    DSCR1L1 antibody (N-term) (Cat. #AP6316b)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DSCR1L1 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - DSCR1L1 Antibody (N-term) AP6316b
    DSCR1L1 Antibody (N-term) (Cat. #AP6316b) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession Q14206
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 21997 Da
Antigen Region 6-37 aa
Additional Information
Gene ID 10231
Other Names Calcipressin-2, Down syndrome candidate region 1-like 1, Myocyte-enriched calcineurin-interacting protein 2, MCIP2, Regulator of calcineurin 2, Thyroid hormone-responsive protein ZAKI-4, RCAN2, DSCR1L1, ZAKI4
Target/Specificity This DSCR1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-37 amino acids from the N-terminal region of human DSCR1L1.
Dilution WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDSCR1L1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RCAN2
Synonyms DSCR1L1, ZAKI4
Function Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Tissue Location Expressed in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas
Research Areas
Citations ( 0 )

Background

DSCR1L1 inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. This protein may play a role during central nervous system development. Expression is detected in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas. Expression of both transcripts is upregulated by physiologic concentrations of the thyroid hormone triiodothyroxine.

References

Rothermel, B., et al., J. Biol. Chem. 275(12):8719-8725 (2000).
Fuentes, J.J., et al., Hum. Mol. Genet. 9(11):1681-1690 (2000).
Strippoli, P., et al., Genomics 64(3):252-263 (2000).
Miyazaki, T., et al., J. Biol. Chem. 271(24):14567-14571 (1996).
Cao, X., et al., Biochem. J. 367 (PT 2), 459-466 (2002) (): ().

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$ 295.00
$ 99.00
Cat# AP6316b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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