|Application ||WB, E|
|Other Accession||P61142, Q3T0G8, Q3I5G7, NP_000336|
|Predicted||Bovine, Monkey, Pig|
|Calculated MW||14460 Da|
|Antigen Region||104-133 aa|
|Other Names||Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, SNCA, NACP, PARK1|
|Target/Specificity||This SNCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the C-terminal region of human SNCA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNCA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.|
|Cellular Location||Cytoplasm, cytosol Membrane. Nucleus. Cell junction, synapse. Secreted. Note=Membrane-bound in dopaminergic neurons.|
|Tissue Location||Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals|
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Provided below are standard protocols that you may find useful for product applications.
Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues. Two alternatively spliced transcripts of Alpha Synuclein have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined. This variant (NACP140) is the longer transcript and encodes the longer isoform (NACP140). This antibody specific recognizing Alpha-synuclein isoform NACP140 not NACP112.
Kumru, H., et al., Ann. Neurol. 56(4):599-603 (2004).
Pigullo, S., et al., Parkinsonism Relat. Disord. 10(6):357-362 (2004).
Yao, D., et al., Proc. Natl. Acad. Sci. U.S.A. 101(29):10810-10814 (2004).
West, A.B., et al., J. Biol. Chem. 279(28):28896-28902 (2004).
Wang, F., et al., Genes Chromosomes Cancer 40(2):85-96 (2004).
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