|Application ||WB, IF, FC, E|
|Other Accession||P26684, Q61614|
|Calculated MW||48722 Da|
|Antigen Region||125-154 aa|
|Other Names||Endothelin-1 receptor, Endothelin A receptor, ET-A, ETA-R, hET-AR, EDNRA, ETA, ETRA|
|Target/Specificity||This EDNRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-154 amino acids from the Central region of human EDNRA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EDNRA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.|
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Provided below are standard protocols that you may find useful for product applications.
EDNRA is a receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Cardillo,C., Arthritis Rheum. 60 (6), 1840-1844 (2009) Hayzer,D.J., Am. J. Med. Sci. 304 (4), 231-238 (1992)
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