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EDNRA Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - EDNRA Antibody (Center) AP6507C
    Western blot analysis of EDNRA antibody (Center) (Cat.# AP6507c) in CEM cell line lysates (35ug/lane). EDNRA (arrow) was detected using the purified Pab.
  • IF - EDNRA Antibody (Center) AP6507C
    Confocal immunofluorescent analysis of EDNRA Antibody (Center)(Cat#AP6507c) with HepG2 cell followed by Alexa Fluor搴?488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
  • FC - EDNRA Antibody (Center) AP6507C
    Flow cytometric analysis of CEM cells using EDNRA Antibody (Center) (green histogram) compared to a negative control cell (blue histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P25101
Other Accession P26684, Q61614
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 48722 Da
Antigen Region 125-154 aa
Additional Information
Gene ID 1909
Other Names Endothelin-1 receptor, Endothelin A receptor, ET-A, ETA-R, hET-AR, EDNRA, ETA, ETRA
Target/Specificity This EDNRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-154 amino acids from the Central region of human EDNRA.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEDNRA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ETA, ETRA
Function Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.
Research Areas
Citations (0)

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EDNRA is a receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.


Cardillo,C., Arthritis Rheum. 60 (6), 1840-1844 (2009) Hayzer,D.J., Am. J. Med. Sci. 304 (4), 231-238 (1992)

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Cat# AP6507C
(40 western blots)
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