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ABCG1 Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP6529a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ABCG1 Antibody (N-term) - Product info | |
| Application | WB, FC, IHC, IF
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| Primary Accession | P45844 |
| Other Accession | Q64343 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 75592 Da |
ABCG1 Antibody (N-term) - Additional info | |
| Gene ID 9619 | |
| Other Names ABCG1; ABC8; WHT1; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; White protein homolog | |
| Target/Specificity This ABCG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174~204 amino acids from the N-terminal region of human ABCG1. | |
| Dilution WB~~1:50~100WB~~1:1000 FC~~1:10~50 IHC~~1:50~100 IF~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABCG1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABCG1 Antibody (N-term) - Protein Information | |
| Name ABCG1 | |
| Synonyms ABC8, WHT1 | |
| Function Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages | |
| Cellular Location Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes | |
| Tissue Location Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease | |
ABCG1 Antibody (N-term) - Related products
AP6529a: ABCG1 Antibody (N-term)
AP6529c: ABCG1 Antibody (Center)
RI10029: ABCG1 predesign siRNA
BP6529a: ABCG1 Antibody (N-term) Blocking Peptide
BP6529c: ABCG1 Antibody (Center) Blocking Peptide
ABCG1 Antibody (N-term) - Application data
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Western blot analysis of ABCG1 antibody (N-term) (Cat.# AP6529a) in mouse spleen tissue lysates (35ug/lane). ABCG1 (arrow) was detected using the purified Pab.
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ABCG1 Antibody (N-term) (Cat.#AP6529a) flow cytometry analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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ABCG1 Antibody (N-term) (Cat. #AP6529a) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCG1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Confocal immunofluorescent analysis of ABCG1 Antibody (N-term)(Cat#AP6529a) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
ABCG1 Antibody (N-term) - Research Areas
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BACKGROUND
ABCG1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types.
REFERENCES
Furuyama,S., J. Atheroscler. Thromb. 16 (3), 194-200 (2009) Stefulj,J., Circ. Res. 104 (5), 600-608 (2009) Mauerer,R., Exp. Mol. Med. 41 (2), 126-132 (2009)
