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ABCG1 Antibody (Center)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP6529c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
ABCG1 Antibody (Center) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | P45844 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 75592 Da |
ABCG1 Antibody (Center) - Additional info | |
| Gene ID 9619 | |
| Other Names ABCG1; ABC8; WHT1; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; White protein homolog | |
| Target/Specificity This ABCG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366~395 amino acids from the Center region of human ABCG1. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABCG1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABCG1 Antibody (Center) - Protein Information | |
| Name ABCG1 | |
| Synonyms ABC8, WHT1 | |
| Function Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages | |
| Cellular Location Mitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes | |
| Tissue Location Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease | |
ABCG1 Antibody (Center) - Related products
AP6529a: ABCG1 Antibody (N-term)
AP6529c: ABCG1 Antibody (Center)
RI10029: ABCG1 predesign siRNA
BP6529a: ABCG1 Antibody (N-term) Blocking Peptide
BP6529c: ABCG1 Antibody (Center) Blocking Peptide
ABCG1 Antibody (Center) - Application data
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Western blot analysis of ABCG1 Antibody (Center) (Cat. #AP6529c) in 293 cell line lysates (35ug/lane). ABCG1 (arrow) was detected using the purified Pab.
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Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with ABCG1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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ABCG1 Antibody (Center) (Cat.#AP6529c) flow cytometry analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
ABCG1 Antibody (Center) - Research Areas
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BACKGROUND
ABCG1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types.
REFERENCES
Furuyama,S., J. Atheroscler. Thromb. 16 (3), 194-200 (2009) Stefulj,J., Circ. Res. 104 (5), 600-608 (2009) Mauerer,R., Exp. Mol. Med. 41 (2), 126-132 (2009)
