|Application ||WB, IHC-P, E|
|Calculated MW||70858 Da|
|Antigen Region||66-96 aa|
|Other Names||Carnitine O-acetyltransferase, Carnitine acetylase, Carnitine acetyltransferase, CAT, CrAT, CRAT, CAT1|
|Target/Specificity||This CRAT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-96 amino acids from the N-terminal region of human CRAT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CRAT Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.|
|Cellular Location||Endoplasmic reticulum. Peroxisome. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side Isoform 2: Peroxisome.|
|Tissue Location||Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney|
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Provided below are standard protocols that you may find useful for product applications.
CRAT is carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments.
Govindasamy,L., J. Struct. Biol. 146 (3), 416-424 (2004)
Jogl,G., Cell 112 (1), 113-122 (2003)
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