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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CREB3L1 Antibody (C-term)   

CREB3L1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CREB3L1 Antibody (C-term) AP6589B
    Anti-CREB3L1 Antibody (C-term) at 1:8000 dilution + HepG2 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 57 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - CREB3L1 Antibody (C-term) AP6589B
    Western blot analysis of CREB3L1 Antibody (C-term) (Cat. #AP6589b) in mouse stomach tissue lysates (35ug/lane). CREB3L1 (arrow) was detected using the purified Pab.
  • IHC-P - CREB3L1 Antibody (C-term) AP6589B
    Formalin-fixed and paraffin-embedded human prostate carcinoma with CREB3L1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - CREB3L1 Antibody (C-term) AP6589B
    Flow cytometric analysis of hela cells using CREB3L1 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession Q96BA8
Other Accession NP_443086
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57005 Da
Antigen Region 481-509 aa
Additional Information
Gene ID 90993
Other Names Cyclic AMP-responsive element-binding protein 3-like protein 1, cAMP-responsive element-binding protein 3-like protein 1, Old astrocyte specifically-induced substance, OASIS, Processed cyclic AMP-responsive element-binding protein 3-like protein 1, CREB3L1, OASIS
Target/Specificity This CREB3L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 481-509 amino acids from the C-terminal region of human CREB3L1.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCREB3L1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CREB3L1
Synonyms OASIS
Function Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity).
Cellular Location Endoplasmic reticulum membrane; Single-pass type II membrane protein
Tissue Location Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain.
Research Areas
Citations (0)

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Background

CREB3L1 is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. It is specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). It may play a role in gliosis. In vitro, it binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.

References

Guillou,L., Am. J. Surg. Pathol. 31 (9), 1387-1402 (2007)
Omori,Y., Biochem. Biophys. Res. Commun. 293 (1), 470-477 (2002)

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$ 295.00
$ 99.00
Cat# AP6589B
Size:
Quantity:
(40 western blots)
Availability: In Stock
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