|Application ||WB, IHC-P, FC, E|
|Other Accession||Q8VHW8, Q8VHW4|
|Calculated MW||30903 Da|
|Antigen Region||192-220 aa|
|Other Names||Voltage-dependent calcium channel gamma-5 subunit, Neuronal voltage-gated calcium channel gamma-5 subunit, Transmembrane AMPAR regulatory protein gamma-5, TARP gamma-5, CACNG5|
|Target/Specificity||This CACNG5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-220 amino acids from the C-terminal region of human CACNG5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CACNG5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density|
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Provided below are standard protocols that you may find useful for product applications.
L-type calcium channels are composed of five subunits. The protein CACNG5 represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state.
Chu,P.J., Gene 280 (1-2), 37-48 (2001)
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