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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PRELP Antibody (C-term)   

PRELP Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PRELP Antibody (C-term) AP6665b
    Western blot analysis of PRELP antibody (C-term) (Cat. #AP6665b) in Y79 cell line lysates (35ug/lane). PRELP (arrow) was detected using the purified Pab.
  • IHC-P - PRELP Antibody (C-term) AP6665b
    Formalin-fixed and paraffin-embedded human hepatocarcinoma with PRELP Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - PRELP Antibody (C-term) AP6665b
    Flow cytometric analysis of widr cells using PRELP Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession P51888
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 43810 Da
Antigen Region 257-286 aa
Additional Information
Gene ID 5549
Other Names Prolargin, Proline-arginine-rich end leucine-rich repeat protein, PRELP, SLRR2A
Target/Specificity This PRELP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino acids from the C-terminal region of human PRELP.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRELP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRELP
Synonyms SLRR2A
Function May anchor basement membranes to the underlying connective tissue.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Connective tissue.
Research Areas
Citations (0)

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Background

PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage.

References

Grover,J., Matrix Biol. 26 (2), 140-143 (2007)
Johnson,J.M., Mol. Vis. 12, 1057-1066 (2006)
Lewis,M., Ageing Res. Rev. 2 (1), 95-105 (2003)

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Cat# AP6665b
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