|Application ||WB, IHC-P, E|
|Calculated MW||43810 Da|
|Antigen Region||119-148 aa|
|Other Names||Prolargin, Proline-arginine-rich end leucine-rich repeat protein, PRELP, SLRR2A|
|Target/Specificity||This PRELP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-148 amino acids from the Central region of human PRELP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRELP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May anchor basement membranes to the underlying connective tissue.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Connective tissue.|
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Provided below are standard protocols that you may find useful for product applications.
PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage.
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Grover, J., et al. Matrix Biol. 26(2):140-143(2007)
Johnson, J.M., et al. Mol. Vis. 12, 1057-1066 (2006)
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