|Application ||WB, IHC-P, E|
|Calculated MW||35709 Da|
|Antigen Region||162-190 aa|
|Other Names||Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733-1, TACSTD2, GA733-1, M1S1, TROP2|
|Target/Specificity||This TROP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-190 amino acids from the Central region of human TROP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TROP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GA733-1, M1S1, TROP2|
|Function||May function as a growth factor receptor.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Placenta, pancreatic carcinoma cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
TROP2 is a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of its gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
Goldstein,A.S., Proc. Natl. Acad. Sci. U.S.A. 105 (52), 20882-20887 (2008)
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