|Application ||WB, IHC-P, FC, E|
|Calculated MW||37833 Da|
|Antigen Region||171-200 aa|
|Other Names||Paired box protein Pax-4, PAX4|
|Target/Specificity||This PAX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-200 amino acids from the Central region of human PAX4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAX4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity.|
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Provided below are standard protocols that you may find useful for product applications.
PAX4 is a member of the paired box (PAX) family of transcription factors. These proteins play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.
Hata,S., Int. J. Oncol. 33 (5), 1065-1071 (2008)
Zhang,Y., Diabetes Res. Clin. Pract. 81 (3), 365-369 (2008)
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