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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LRG1 Antibody (Center)   

LRG1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - LRG1 Antibody (Center) AP6705c
    Western blot analysis of LRG1 antibody (Center) (Cat. #AP6705c) in 293 cell line lysates (35ug/lane). LRG1 (arrow) was detected using the purified Pab.
  • IHC-P - LRG1 Antibody (Center) AP6705c
    Formalin-fixed and paraffin-embedded human lung carcinoma reacted with LRG1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - LRG1 Antibody (Center) AP6705c
    LRG1 Antibody (Center)(Cat. #AP6705c) flow cytometry analysis of 293 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • WB - LRG1 Antibody (Center) AP6705c
    Western blot analysis of LRG1 (arrow) using rabbit polyclonal LRG1 Antibody (Center) (Cat. #AP6705c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the LRG1 gene.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession P02750
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 194-223 aa
Additional Information
Other Names Leucine-rich alpha-2-glycoprotein, LRG, LRG1, LRG
Target/Specificity This LRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-223 amino acids from the Central region of human LRG1.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLRG1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRG1
Synonyms LRG
Cellular Location Secreted.
Tissue Location Plasma. EMBL; AF403428; AAK95527.1; -; mRNA EMBL; BC034389; AAH34389.1; -; mRNA EMBL; BC070198; AAH70198.1; -; mRNA CCDS; CCDS12130.1; - PIR; A03211; NBHUA2 RefSeq; NP_443204.1; NM_052972.2 UniGene; Hs.655559; - ProteinModelPortal; P02750; - SMR; P02750; - BioGrid; 125537; 2 DIP; DIP-60317N; - IntAct; P02750; 5 STRING; 9606.ENSP00000302621; - GlyConnect; 676; - iPTMnet; P02750; - PhosphoSitePlus; P02750; - UniCarbKB; P02750; - BioMuta; LRG1; - DMDM; 23503037; - DOSAC-COBS-2DPAGE; P02750; - SWISS-2DPAGE; P02750; - EPD; P02750; - PaxDb; P02750; - PeptideAtlas; P02750; - PRIDE; P02750; - ProteomicsDB; 51566; - DNASU; 116844; - Ensembl; ENST00000306390; ENSP00000302621; ENSG00000171236 GeneID; 116844; - KEGG; hsa:116844; - UCSC; uc002mau.4; human CTD; 116844; - DisGeNET; 116844; - EuPathDB; HostDB:ENSG00000171236.9; - GeneCards; LRG1; - HGNC; HGNC:29480; LRG1 HPA; HPA001888; - HPA; HPA001889; - MIM; 611289; gene neXtProt; NX_P02750; - OpenTargets; ENSG00000171236; - PharmGKB; PA134919634; - eggNOG; KOG0619; Eukaryota eggNOG; COG4886; LUCA GeneTree; ENSGT00920000148996; - HOGENOM; HOG000234378; - HOVERGEN; HBG000045; - InParanoid; P02750; - OMA; DTRCAGP; - OrthoDB; EOG091G0RZG; - PhylomeDB; P02750; - TreeFam; TF351919; - Reactome; R-HSA-6798695; Neutrophil degranulation GeneWiki; LRG1; - GenomeRNAi; 116844; - PRO; PR:P02750; - Proteomes; UP000005640; Chromosome 19 Bgee; ENSG00000171236; - CleanEx; HS_LRG1; - Genevisible; P02750; HS GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB GO; GO:0005576; C:extracellular region; HDA:BHF-UCL GO; GO:0005615; C:extracellular space; IDA:MGI GO; GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA GO; GO:0016020; C:membrane; NAS:UniProtKB GO; GO:0035580; C:specific granule lumen; TAS:Reactome GO; GO:1904724; C:tertiary granule lumen; TAS:Reactome GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:Ensembl GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl GO; GO:0009617; P:response to bacterium; IEA:Ensembl Gene3D; 3.80.10.10; -; 2 InterPro; IPR000483; Cys-rich_flank_reg_C InterPro; IPR001611; Leu-rich_rpt InterPro; IPR003591; Leu-rich_rpt_typical-subtyp InterPro; IPR032675; LRR_dom_sf Pfam; PF13855; LRR_8; 2 SMART; SM00369; LRR_TYP; 7 SMART; SM00082; LRRCT; 1 PROSITE; PS51450; LRR; 8 1: Evidence at protein level; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Leucine-rich repeat; Polymorphism; Reference proteome; Repeat; Secreted; Signal SIGNAL 1 35 CHAIN 36 347 Leucine-rich alpha-2-glycoprotein /FTId=PRO_0000020579 REPEAT 93 114 LRR 1 REPEAT 117 138 LRR 2 REPEAT 141 162 LRR 3 REPEAT 165 186 LRR 4 REPEAT 189 210 LRR 5 REPEAT 213 234 LRR 6 REPEAT 237 258 LRR 7 REPEAT 261 282 LRR 8 DOMAIN 299 347 LRRCT SITE 306 306 Not glycosylated CARBOHYD 37 37 O-linked (GalNAc...) threonine CARBOHYD 79 79 N-linked (GlcNAc...) (complex) asparagine CARBOHYD 186 186 N-linked (GlcNAc...) (complex) asparagine. CARBOHYD 269 269 N-linked (GlcNAc...) asparagine CARBOHYD 325 325 N-linked (GlcNAc...) (complex) asparagine. DISULFID 43 56 DISULFID 303 329 VARIANT 64 64 G -> S (in dbSNP:rs7251081) /FTId=VAR_050629 VARIANT 133 133 P -> S (in dbSNP:rs966384) /FTId=VAR_024245 SEQUENCE 347 AA; 38178 MW; 20C99ED50152FA9C CRC64; MSSWSRQRPK SPGGIQPHVS RTLFLLLLLA ASAWGVTLSP KDCQVFRSDH GSSISCQPPA EIPGYLPADT VHLAVEFFNL THLPANLLQG ASKLQELHLS SNGLESLSPE FLRPVPQLRV LDLTRNALTG LPPGLFQASA TLDTLVLKEN QLEVLEVSWL HGLKALGHLD LSGNRLRKLP PGLLANFTLL RTLDLGENQL ETLPPDLLRG PLQLERLHLE GNKLQVLGKD LLLPQPDLRY LFLNGNKLAR VAAGAFQGLR QLDMLDLSNN SLASVPEGLW ASLGQPNWDM RDGFDISGNP WICDQNLSDL YRWLQAQKDK MFSQNDTRCA GPEAVKGQTL LAVAKSQ
Research Areas
Citations (0)

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Background

The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation.

References

Shirai,R., Biochem. Biophys. Res. Commun. 382 (4), 776-779 (2009)
Gillott,D.J., Fertil. Steril. 90 (3), 761-768 (2008)

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$ 295.00
$ 99.00
Cat# AP6705c
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(40 western blots)
Availability: In Stock
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