|Application ||WB, IHC-P, FC, E|
|Calculated MW||122293 Da|
|Antigen Region||640-665 aa|
|Other Names||Mastermind-like protein 3, Mam-3, MAML3 (HGNC:16272)|
|Target/Specificity||This MAML3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 640-665 amino acids from the C-terminal region of human MAML3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAML3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.|
|Cellular Location||Nucleus speckle. Note=Nuclear, in a punctate manner|
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Provided below are standard protocols that you may find useful for product applications.
MAML3 acts as a transcriptional coactivator for NOTCH proteins. The protein has been shown to amplify NOTCH-induced transcription of HES1.
Tonon,G., Nat. Genet. 33 (2), 208-213 (2003)
Lin,S.E., J. Biol. Chem. 277 (52), 50612-50620 (2002)
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