|Application ||WB, E|
|Calculated MW||14700 Da|
|Antigen Region||55-83 aa|
|Other Names||Follitropin subunit beta, Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain, FSHB|
|Target/Specificity||This FSHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the Central region of human FSHB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FSHB Antibody (Center T70) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432).|
|Cellular Location||Secreted. Note=Efficient secretion requires dimerization with CGA|
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Provided below are standard protocols that you may find useful for product applications.
FSHB stimulates development of follicle and spermatogenesis in the reproductive organs.
Grigorova,M., et.al., J. Clin. Endocrinol. Metab. (2009)
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