|Application ||WB, IHC-P, E|
|Other Accession||Q96QG7, NP_060147|
|Calculated MW||63462 Da|
|Antigen Region||518-549 aa|
|Other Names||Myotubularin-related protein 9, 313-, MTMR8|
|Target/Specificity||This MTMR8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 518-549 amino acids from the C-terminal region of human MTMR8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MTMR9 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential).|
|Tissue Location||Expressed in many tissues.|
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Provided below are standard protocols that you may find useful for product applications.
MTMR8 is a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.
Appel, S., et al., Eur. J. Hum. Genet. 10(1):17-25 (2002).
Appel, S., et al., Genomics 75 (1-3), 6-8 (2001).
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