- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Calculated MW||71174 Da|
|Antigen Region||20-48 aa|
|Other Names||Fragile X mental retardation protein 1, FMRP, Protein FMR-1, FMR1|
|Target/Specificity||This FMR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-48 amino acids from the N-terminal region of human FMR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FMR1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).|
|Cellular Location||Cytoplasm. Nucleus, nucleolus.|
|Tissue Location||Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells|
Provided below are standard protocols that you may find useful for product applications.
FMR1 binds RNA and is associated with polysomes. This protein may be involved in mRNA trafficking from the nucleus to the cytoplasm.
Yuhas,J., et.al., Genet Test Mol Biomarkers 13 (6), 855-859 (2009)
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