|Application ||WB, IHC-P, FC, E|
|Calculated MW||25982 Da|
|Antigen Region||24-51 aa|
|Other Names||Protein FAM3B, Cytokine-like protein 2-21, Pancreatic-derived factor, PANDER, FAM3B, C21orf11, C21orf76|
|Target/Specificity||This FAM3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human FAM3B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FAM3B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.|
|Cellular Location||Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure|
|Tissue Location||Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis|
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Provided below are standard protocols that you may find useful for product applications.
FAM3B has delayed effects on beta-cell function, inhibiting basal insulin secretion from a beta-cell line in a dose-dependent manner.
Yang,J., et.al., Biochemistry 44 (34), 11342-11352 (2005)
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