|Application ||WB, IHC-P, IF, E|
|Calculated MW||46683 Da|
|Antigen Region||352-380 aa|
|Other Names||Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2|
|Target/Specificity||This PAX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352-380 amino acids from human PAX6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAX6-T373 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.|
|Tissue Location||Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form|
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Provided below are standard protocols that you may find useful for product applications.
PAX6 encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly.
Zhang, Y., et al. J. Biol. Chem. 285(4):2527-2536(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Schmidt-Sidor, B., et al. Folia Neuropathol 47(4):372-382(2009)
Ng, T.K., et al. Mol. Vis. 15, 2239-2248 (2009)
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