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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PAX6-T373 Antibody   

PAX6-T373 Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PAX6-T373 Antibody AP6929d
    Anti-PAX6-T373 Antibody at 1:2000 dilution + rat eyeball lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 47 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - PAX6-T373 Antibody AP6929d
    Western blot analysis of PAX6-T373 (Cat. #AP6929d) in Y79 cell line lysates (35ug/lane). PAX6 (arrow) was detected using the purified Pab.
  • WB - PAX6-T373 Antibody AP6929d
    Western blot analysis of PAX6 (arrow) using rabbit polyclonal PAX6 Antibody (T373) (Cat. #AP6929d). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PAX6 gene.
  • IHC-P - PAX6-T373 Antibody AP6929d
    PAX6-T373 Antibody (Cat. #AP6929d) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PAX6-T373 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
  • IF - PAX6-T373 Antibody AP6929d
    Confocal immunofluorescent analysis of PAX6-T373 Antibody(Cat#AP6929d) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P26367
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46683 Da
Antigen Region 352-380 aa
Additional Information
Gene ID 5080
Other Names Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2
Target/Specificity This PAX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352-380 amino acids from human PAX6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPAX6-T373 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PAX6
Synonyms AN2
Function Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
Cellular Location Nucleus.
Tissue Location Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form
Research Areas
Citations (0)

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PAX6 encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly.


Zhang, Y., et al. J. Biol. Chem. 285(4):2527-2536(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Schmidt-Sidor, B., et al. Folia Neuropathol 47(4):372-382(2009)
Ng, T.K., et al. Mol. Vis. 15, 2239-2248 (2009)

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$ 295.00
$ 99.00
Cat# AP6929d
(40 western blots)
Availability: In Stock
Bulk Size
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