|Application ||WB, IHC-P, E|
|Calculated MW||30084 Da|
|Antigen Region||56-85 aa|
|Other Names||Cerberus, Cerberus-related protein, DAN domain family member 4, CER1, DAND4|
|Target/Specificity||This CER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the N-terminal region of human CER1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CER1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CER1 is a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity.
Tang,P.L., et.al., J. Bone Miner. Res. 24 (6), 1013-1021 (2009)
Swinkels,M.E., et.al., Am. J. Med. Genet. A 146A (11), 1430-1438 (2008)
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