|Application ||WB, IHC-P, E|
|Calculated MW||30084 Da|
|Antigen Region||56-85 aa|
|Other Names||Cerberus, Cerberus-related protein, DAN domain family member 4, CER1, DAND4|
|Target/Specificity||This CER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the N-terminal region of human CER1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CER1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
CER1 is a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity.
Tang,P.L., et.al., J. Bone Miner. Res. 24 (6), 1013-1021 (2009)
Swinkels,M.E., et.al., Am. J. Med. Genet. A 146A (11), 1430-1438 (2008)
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