- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Calculated MW||39836 Da|
|Antigen Region||281-308 aa|
|Other Names||Homer protein homolog 3, Homer-3, HOMER3|
|Target/Specificity||This HOMER3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-308 amino acids from the Central region of human HOMER3.|
|Precautions||HOMER3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.|
|Cellular Location||Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse Note=Postsynaptic density of neuronal cells.|
Provided below are standard protocols that you may find useful for product applications.
HOMER3 is a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. This protein binds numerous other proteins including group I metabotropic glutamate receptors,inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides.
Norton,N., et.al., Am. J. Med. Genet. B Neuropsychiatr. Genet. 120B (1), 18-21 (2003)
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