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HOMER3 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HOMER3 Antibody (Center) AP6992c
    Western blot analysis of HOMER3 Antibody (Center) (Cat. #AP6992c) in MDA-MB231 cell line lysates (35ug/lane).HOMER3 (arrow) was detected using the purified Pab.
  • WB - HOMER3 Antibody (Center) AP6992c
    Western blot analysis of HOMER3 Antibody (Center) (Cat. #AP6992c) in mouse NIH-3T3 cell line lysates (35ug/lane).HOMER3 (arrow) was detected using the purified Pab.
  • IHC-P - HOMER3 Antibody (Center) AP6992c
    Formalin-fixed and paraffin-embedded human brain tissue with HOMER3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - HOMER3 Antibody (Center) AP6992c
    Flow cytometric analysis of SK-Br-3 cells using HOMER3 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • WB - HOMER3 Antibody (Center) AP6992c
    Western blot analysis of HOMER3 (arrow) using rabbit polyclonal HOMER3 Antibody (Center) (Cat. #AP6992c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the HOMER3 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NSC5
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 39836 Da
Antigen Region 281-308 aa
Additional Information
Gene ID 9454
Other Names Homer protein homolog 3, Homer-3, HOMER3
Target/Specificity This HOMER3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-308 amino acids from the Central region of human HOMER3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHOMER3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
Cellular Location Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse Note=Postsynaptic density of neuronal cells.
Research Areas
Citations ( 0 )


HOMER3 is a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. This protein binds numerous other proteins including group I metabotropic glutamate receptors,inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides.


Norton,N.,, Am. J. Med. Genet. B Neuropsychiatr. Genet. 120B (1), 18-21 (2003)

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$ 295.00
$ 99.00
Cat# AP6992c
(40 western blots)
Availability: In Stock
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