|Application ||WB, E|
|Calculated MW||63283 Da|
|Antigen Region||270-299 aa|
|Other Names||Serine/threonine-protein kinase RIO2, RIO kinase 2, RIOK2|
|Target/Specificity||This RIOK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-299 amino acids from the Central region of human RIOK2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RIOK2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).|
|Cellular Location||Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner.|
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Provided below are standard protocols that you may find useful for product applications.
RIOK2 belongs to the protein kinase superfamily; RIO-type Ser/Thr kinase family. Serine/threonine protein kinases, such as RIOK2, phosphorylate the OH group of serine or threonine (which have similar sidechains). Activity of these protein kinases can be regulated by specific events (e.g. DNA damage), as well as numerous chemical signals, including cAMP/cGMP, Diacylglycerol, and Ca2+/calmodulin.
Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
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