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ADK Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP7091b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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ADK Antibody (C-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | P55263 |
| Other Accession | NP_006712 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 40545 Da |
ADK Antibody (C-term) - Additional info | |
| Gene ID 132 | |
| Other Names ADK; Adenosine kinase; Adenosine 5'-phosphotransferase | |
| Target/Specificity This ADK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ADK. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ADK Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ADK Antibody (C-term) - Protein Information | |
| Name ADK | |
| Function ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides | |
| Tissue Location Widely expressed. Highest level in placenta, liver, muscle and kidney | |
ADK Antibody (C-term) - Related products
AP7091a: ADK Antibody (N-term)
AP7091b: ADK Antibody (C-term)
LY10132a: ADK Over-expression Lysate
ADK Antibody (C-term) - Application data
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Western blot analysis of anti-ADK Pab (Cat. #AP7091b) in mouse liver tissue lysate (35ug/lane). ADK(arrow) was detected using the purified Pab (1:60 dilution).
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Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ADK antibody (C-term) (Cat.#AP7091b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
ADK Antibody (C-term) - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Adenosine kinase is an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg2+ for activity.
REFERENCES
Szkotak, A.J., et al., J. Membr. Biol. 192(3):169-179 (2003). Singh, B., et al., DNA Cell Biol. 20(1):53-65 (2001). Van Rompay, A.R., et al., Eur. J. Biochem. 261(2):509-517 (1999). Mathews, I.I., et al., Biochemistry 37(45):15607-15620 (1998). McNally, T., et al., Biochem. Biophys. Res. Commun. 231(3):645-650 (1997).
