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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   NEK8 Antibody (C-term)   

NEK8 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NEK8 Antibody (C-term) AP7095b
    The anti-NEK8 Pab (Cat. #AP7095b) is used in Western blot to detect NEK8 in A2058 cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86SG6
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 74806 Da
Antigen Region 573-604 aa
Additional Information
Gene ID 284086
Other Names Serine/threonine-protein kinase Nek8, Never in mitosis A-related kinase 8, NimA-related protein kinase 8, Nima-related protein kinase 12a, NEK8, JCK, NEK12A
Target/Specificity This NEK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 573-604 amino acids from the C-terminal region of human NEK8.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNEK8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEK8
Synonyms JCK, NEK12A
Function Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells
Tissue Location Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma
Research Areas
Citations (0)

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NEK8 is a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans.


Valkova,N. et al. Mol. Cell Proteomics 4 (7), 1009-1018 (2005)
Bowers,A.J. et al. Gene 328, 135-142 (2004)
Holland,P.M. et al. J. Biol. Chem. 277 (18), 16229-16240 (2002)

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$ 295.00
$ 99.00
Cat# AP7095b
(40 western blots)
Availability: In Stock
Bulk Size
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