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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Activin A Receptor Type IC (ACVR1C) Antibody (N-term A48)   

Activin A Receptor Type IC (ACVR1C) Antibody (N-term A48)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Activin A Receptor Type IC (ACVR1C) Antibody (N-term A48) AP7102a
    Western blot analysis of anti-ACVR1C Antibody (N-term A48) (Cat.#AP7102a) in HepG2 and Hela cell line lysate (35ug/lane). ACVR1C (arrow) was detected using the purified Pab.
  • IHC-P - Activin A Receptor Type IC (ACVR1C) Antibody (N-term A48) AP7102a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q8NER5
Other Accession Q8K348
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 54871 Da
Antigen Region 33-62 aa
Additional Information
Gene ID 130399
Other Names Activin receptor type-1C, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, ACVR1C (HGNC:18123)
Target/Specificity This Activin A Receptor Type IC (ACVR1C) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human Activin A Receptor Type IC (ACVR1C).
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsActivin A Receptor Type IC (ACVR1C) Antibody (N-term A48) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACVR1C (HGNC:18123)
Function Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy
Research Areas
Citations ( 0 )

Background

ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.

References

Munir, S., et al., J. Biol. Chem. 279(30):31277-31286 (2004).
Kim, B.C., et al., J. Biol. Chem. 279(27):28458-28465 (2004).
Roberts, H.J., et al., Biol. Reprod. 68(5):1719-1726 (2003).
Tsuchida, K., et al., Mol. Cell. Endocrinol. 220 (1-2), 59-65 (2004) (): ().
Bondestam, J., et al., Cytogenet. Cell Genet. 95 (3-4), 157-162 (2001) (): ().

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$ 295.00
$ 99.00
Cat# AP7102a
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(40 western blots)
Availability: In Stock
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