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ACVR2A Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP7103a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
ACVR2A Antibody (N-term) - Product info | |
| Application | WB
|
| Primary Accession | P27037 |
| Other Accession | P38444, P27038, Q90669, Q28043 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Mouse, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 57848 Da |
ACVR2A Antibody (N-term) - Additional info | |
| Gene ID 92 | |
| Other Names ACVR2A; ACVR2; Activin receptor type-2A; Activin receptor type IIA | |
| Target/Specificity This ACVR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR2A. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ACVR2A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ACVR2A Antibody (N-term) - Protein Information | |
| Name ACVR2A | |
| Synonyms ACVR2 | |
| Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A | |
| Cellular Location Membrane; Single-pass type I membrane protein | |
ACVR2A Antibody (N-term) - Related products
AP7103a: ACVR2A Antibody (N-term)
RI10100: ACVR2A predesign siRNA
DC08603: Human ACVR2A cDNA Clone
ACVR2A Antibody (N-term) - Application data
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Western blot analysis of anti-ACVR2A Antibody (N-term) (Cat. #AP7103a) in mouse liver(lane 1) brain(lane 2) and kidney(lane 3) tissue lysates (35ug/lane). ACVR2A (arrow) was detected using the purified Pab.
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Western blot analysis of ACVR2A (arrow) using rabbit polyclonal ACVR2A Antibody (N-term) (Cat.#AP7103a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVR2A gene (Lane 2) (Origene Technologies).
ACVR2A Antibody (N-term) - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
REFERENCES
Jung, B., et al., Gastroenterology 126(3):654-659 (2004). Martins da Silva, S.J., et al., Dev. Biol. 266(2):334-345 (2004). Olaru, A., et al., Lab. Invest. 83(12):1867-1871 (2003). Casagrandi, D., et al., Mol. Hum. Reprod. 9(4):199-203 (2003). Greenwald, J., et al., Mol. Cell 11(3):605-617 (2003).
