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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ACVR2A Antibody (N-term)   

ACVR2A Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ACVR2A Antibody (N-term) AP7103A
    Anti-ACVR2A Antibody (N-term) at 1:1000 dilution + human fetal liver lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 58 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - ACVR2A Antibody (N-term) AP7103A
    Anti-ACVR2A Antibody (N-term) at 1:2000 dilution + mouse liver lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 57. 8 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - ACVR2A Antibody (N-term) AP7103A
    Western blot analysis of ACVR2A (arrow) using rabbit polyclonal ACVR2A Antibody (N-term) (Cat.#AP7103a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVR2A gene (Lane 2) (Origene Technologies).
  • IHC-P - ACVR2A Antibody (N-term) AP7103A
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P27037
Other Accession P38444, P27038, Q90669, Q28043, Q28560
Reactivity Human, Mouse
Predicted Mouse, Rat, Chicken, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57848 Da
Antigen Region 2-29 aa
Additional Information
Gene ID 92
Other Names Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA, ACTRIIA, ACVR2A, ACVR2
Target/Specificity This ACVR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-29 amino acids from the N-terminal region of human ACVR2A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsACVR2A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ACVR2
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.


Jung, B., et al., Gastroenterology 126(3):654-659 (2004).
Martins da Silva, S.J., et al., Dev. Biol. 266(2):334-345 (2004).
Olaru, A., et al., Lab. Invest. 83(12):1867-1871 (2003).
Casagrandi, D., et al., Mol. Hum. Reprod. 9(4):199-203 (2003).
Greenwald, J., et al., Mol. Cell 11(3):605-617 (2003).

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$ 295.00
$ 99.00
Cat# AP7103A
(40 western blots)
Availability: In Stock
Bulk Size
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