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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ERN2 Antibody (C-term)   

ERN2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ERN2 Antibody (C-term) AP7128b
    The anti-ERN2 Pab (Cat. #AP7128b) is used in Western blot to detect ERN2 in mouse liver tissue lysate
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q76MJ5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 102480 Da
Antigen Region 781-810 aa
Additional Information
Gene ID 10595
Other Names Serine/threonine-protein kinase/endoribonuclease IRE2, Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, hIRE2p, Ire1-beta, IRE1b, Serine/threonine-protein kinase, Endoribonuclease, 3126-, ERN2 (HGNC:16942)
Target/Specificity This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 781-810 amino acids from the C-terminal region of human ERN2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsERN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ERN2 (HGNC:16942)
Function Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.


Iwawaki, T., et al., Nat. Cell Biol. 3(2):158-164 (2001).
Wang, X.Z., et al., EMBO J. 17(19):5708-5717 (1998).

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$ 295.00
$ 99.00
Cat# AP7128b
(40 western blots)
Availability: In Stock
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