|Application ||WB, IHC-P, E|
|Calculated MW||64339 Da|
|Antigen Region||332-360 aa|
|Other Names||Pantothenate kinase 1, hPanK, hPanK1, Pantothenic acid kinase 1, PANK1, PANK|
|Target/Specificity||This PANK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-360 amino acids from the Central region of human PANK1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PANK1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the physiological regulation of the intracellular CoA concentration.|
|Tissue Location||Isoform 1 is expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis. Isoform 2 is detected at much lower levels in kidney, liver, brain and testis and is not detected in heart or skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
PANK1 belongs to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA.
Ramaswamy, G., et al., J. Lipid Res. 45(1):17-31 (2004).
Ni, X., et al., Int. J. Biochem. Cell Biol. 34(2):109-115 (2002).
Zhou, B., et al., Nat. Genet. 28(4):345-349 (2001).
Westaway, S.K., et al., Int. J. Biochem. Cell Biol. 34 (12), 1629 (2002) (): ().
Robishaw, J.D., et al., Am. J. Physiol. 248 (1 PT 1), E1-E9 (1985) (): ().
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