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CASC3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CASC3 Antibody (C-term) AP7264b
    Western blot analysis of CASC3 (arrow) using rabbit polyclonal CASC3 Antibody (Mouse C-term) (Cat.#AP7264b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CASC3 gene (Lane 2) (Origene Technologies).
  • IHC-P - CASC3 Antibody (C-term) AP7264b
    Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CASC3 Antibody (C-term) (Cat.#AP7264b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8K3W3
Other Accession Q8K3X0, O15234, A5D7H5, NP_619601
Reactivity Human
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 75770 Da
Antigen Region 202-233 aa
Additional Information
Gene ID 192160
Other Names Protein CASC3, Cancer susceptibility candidate gene 3 protein homolog, Metastatic lymph node gene 51 protein homolog, MLN 51 homolog, Protein barentsz, Btz, mBtz, Casc3, Mln51
Target/Specificity This CASC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-233 amino acids from the C-terminal region of human CASC3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCASC3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Casc3
Synonyms Mln51
Function Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA- helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer (By similarity).
Cellular Location Cytoplasm, perinuclear region. Nucleus. Nucleus speckle Note=Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Shuttles between the cytoplasm and the stress granules. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. Colocalizes in nuclear speckles with MAGOH. Under stress condition, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules, which contain stored mRNAs whose translation is stopped in response to stress (By similarity). Predominantly found in the perinuclear region. Shuttles between the nucleus and the cytoplasm in a CRM1- dependent manner.
Tissue Location High levels in heart, brain, including hippocampus and cerebellum, liver, kidney and testis; lower levels in muscle, lung and spleen.
Research Areas
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Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport.


Macchi,P., J. Neurosci. 23 (13), 5778-5788 (2003)
Degot,S., Oncogene 21 (28), 4422-4434 (2002)

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Cat# AP7264b
(40 western blots)
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