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PHB2 Antibody (Y248)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP7270e | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
PHB2 Antibody (Y248) - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q99623 |
| Other Accession | Q5XIH7, O35129, Q2HJ97, NP_009204 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 33296 Da |
PHB2 Antibody (Y248) - Additional info | |
| Gene ID 11331 | |
| Other Names PHB2; BAP; REA; Prohibitin-2; B-cell receptor-associated protein BAP37; D-prohibitin; Repressor of estrogen receptor activity | |
| Target/Specificity This PHB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 233~262 amino acids surrounding Y248 of human PHB2. | |
| Dilution WB~~1:50~100WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions PHB2 Antibody (Y248) is for research use only and not for use in diagnostic or therapeutic procedures. | |
PHB2 Antibody (Y248) - Protein Information | |
| Name PHB2 | |
| Synonyms BAP, REA | |
| Function Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | |
| Cellular Location Mitochondrion inner membrane (By similarity). Cytoplasm (By similarity). Nucleus (By similarity) Note=Also cytoplasmic and nuclear (By similarity) | |
PHB2 Antibody (Y248) - Related products
AP3539a: Phospho-PHB2-Y128 Antibody
AP3622a: Phospho-PHB2-pY248 Antibody
AP7270a: REA (PHB2) Antibody (N-term)
AP7270b: REA (PHB2) Antibody (C-term)
BP3539a: Phospho-PHB2-Y128 Antibody Blocking Peptide
BP3622a: Phospho-PHB2-pY248 Antibody Blocking Peptide
BP7270a: PHB2 Antibody (N-term) Blocking Peptide
PHB2 Antibody (Y248) - Application data
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Western blot analysis of PHB2-Y248(Cat. #AP7270e) in MDA-MB435 cell line lysates (35ug/lane).PHB2 (arrow) was detected using the purified Pab.
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Western blot analysis of PHB2-Y248 (Cat. #AP7270e) in mouse kidney tissue lysates (35ug/lane). PHB2 (arrow) was detected using the purified Pab.
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Western blot analysis of PHB2 (arrow) using PHB2 Antibody (Y248) (Cat. #AP7270e). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PHB2 gene (Lane 2) (Origene Technologies).
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PHB2 Antibody (Y248)(Cat. #AP7270e) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PHB2 Antibody (Y248) for immunohistochemistry. Clinical relevance has not been evaluated.
PHB2 Antibody (Y248) - Research Areas
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BACKGROUND
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. It functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity and is probably involved in regulating mitochondrial respiration activity and in aging.
REFERENCES
Takata,H., Curr. Biol. 17 (15), 1356-1361 (2007) Kasashima,K., J. Biol. Chem. 281 (47), 36401-36410 (2006)
