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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NLRP12 Antibody   

NLRP12 Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NLRP12 Antibody AP7281C
    Western blot analysis of NLRP12 Antibody (Cat. #AP7281c) in HL-60 cell line lysates (35ug/lane). NLRP12 (arrow) was detected using the purified Pab.
  • WB - NLRP12 Antibody AP7281C
    Western blot analysis of NLRP12 Antibody (Cat. #AP7281c) in mouse testis tissue lysates (35ug/lane). NLRP12 (arrow) was detected using the purified Pab.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P59046
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 120173 Da
Additional Information
Gene ID 91662
Other Names NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide, NLRP12, NALP12, PYPAF7, RNO
Target/Specificity This NLRP12 antibody is generated from rabbits immunized with human NLRP12 recombinant protein.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNLRP12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRP12
Synonyms NALP12, PYPAF7, RNO
Function May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
Cellular Location Cytoplasm.
Tissue Location Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
Research Areas
Citations (0)

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Background

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes.

References

Ye,Z., Mol. Cell. Biol. 28 (5), 1841-1850 (2008)
Jeru,I., Proc. Natl. Acad. Sci. U.S.A. 105 (5), 1614-1619 (2008)
Arthur,J.C., J. Immunol. 179 (9), 6291-6296 (2007)

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$ 295.00
$ 99.00
Cat# AP7281C
Size:
Quantity:
(40 western blots)
Availability: In Stock
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