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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GLRX2 Antibody (C-term T135)   

GLRX2 Antibody (C-term T135)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GLRX2 Antibody (C-term T135) AP7301B
    Western blot analysis of GLRX2 antibody (C-term T135) (Cat.#AP7301b) in mouse cerebellum tissue lysates (35ug/lane). GLRX2 (arrow) was detected using the purified Pab.
  • IHC-P - GLRX2 Antibody (C-term T135) AP7301B
    Formalin-fixed and paraffin-embedded human brain reacted with GLRX2 Antibody (C-term T135), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - GLRX2 Antibody (C-term T135) AP7301B
    Flow cytometric analysis of hela cells using GLRX2 Antibody (C-term T135)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NS18
Other Accession Q32L67
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 18052 Da
Antigen Region 120-146 aa
Additional Information
Gene ID 51022
Other Names Glutaredoxin-2, mitochondrial, GLRX2, GRX2
Target/Specificity This GLRX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-146 amino acids from the C-terminal region of human GLRX2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGLRX2 Antibody (C-term T135) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GLRX2
Synonyms GRX2
Function Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Cellular Location Isoform 1: Mitochondrion.
Tissue Location Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes.
Research Areas
Citations (0)

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GLRX2 are a family of glutathione-dependent hydrogen donors that participate in a variety of cellular redox reactions.


Lundberg M., Johansson C. J. Biol. Chem. 276:26269-26275(2001)
Gladyshev V.N., Liu A. J. Biol. Chem. 276:30374-30380(2001)
Lillig C.H. Proc. Natl. Acad. Sci. U.S.A. 101:13227-13232(2004)

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Cat# AP7301B
(40 western blots)
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