|Application ||WB, IHC-P, FC, E|
|Other Accession||Q9Z214, Q9Z2Y3, Q2KJ56|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||40277 Da|
|Antigen Region||96-122 aa|
|Other Names||Homer protein homolog 1, Homer-1, HOMER1, SYN47|
|Target/Specificity||This HOMER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-122 amino acids from the N-terminal region of human HOMER1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HOMER1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.|
|Cellular Location||Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
HOMER1 is a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function.
Sanna,S., Jackson,A.U. Nat. Genet. 40 (2), 198-203 (2008)
Dahl,J.P., Kampman,K.M. Psychiatr. Genet. 15 (4), 277-283 (2005)
Tu,J.C., Xiao,B. Neuron 23 (3), 583-592 (1999)
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