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HOMER1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HOMER1 Antibody (N-term) AP7302a
    Western blot analysis of HOMER1 antibody (N-term) (Cat.#AP7302a) in HepG2 cell line lysates (35ug/lane). HOMER1 (arrow) was detected using the purified Pab.
  • IHC-P - HOMER1 Antibody (N-term) AP7302a
    Formalin-fixed and paraffin-embedded human hepatocarcinoma with HOMER1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - HOMER1 Antibody (N-term) AP7302a
    HOMER1 Antibody (N-term) (Cat.#AP7302a) flow cytometry analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86YM7
Other Accession Q9Z214, Q9Z2Y3, Q2KJ56
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 40277 Da
Antigen Region 96-122 aa
Additional Information
Gene ID 9456
Other Names Homer protein homolog 1, Homer-1, HOMER1, SYN47
Target/Specificity This HOMER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-122 amino acids from the N-terminal region of human HOMER1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHOMER1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms SYN47
Function Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
Cellular Location Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum.
Research Areas
Citations (0)

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HOMER1 is a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function.


Sanna,S., Jackson,A.U. Nat. Genet. 40 (2), 198-203 (2008)
Dahl,J.P., Kampman,K.M. Psychiatr. Genet. 15 (4), 277-283 (2005)
Tu,J.C., Xiao,B. Neuron 23 (3), 583-592 (1999)

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Cat# AP7302a
(40 western blots)
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