|Application ||WB, IHC-P, FC, E|
|Other Accession||P97298, Q95121|
|Calculated MW||46312 Da|
|Antigen Region||279-306 aa|
|Other Names||Pigment epithelium-derived factor, PEDF, Cell proliferation-inducing gene 35 protein, EPC-1, Serpin F1, SERPINF1, PEDF|
|Target/Specificity||This SERPINF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 279-306 amino acids from the Central region of human SERPINF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SERPINF1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.|
|Cellular Location||Secreted. Melanosome. Note=Enriched in stage I melanosomes|
|Tissue Location||Retinal pigment epithelial cells and blood plasma.|
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Provided below are standard protocols that you may find useful for product applications.
SERPINF1 is a member of the serpin family. Serpins are a group of serine protease inhibitors, some of which have also been reported to exhibit neurotrophic activity.
Bessho,H., Kondo,N. Mol. Vis. 15, 1107-1114 (2009)
Petersen,S.V., Valnickova,Z. Biochem. J. 374 (PT 1), 199-206 (2003)
Tombran-Tink,J., Pawar,H. Genomics 19 (2), 266-272 (1994)
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