|Application ||WB, IHC-P, FC, E|
|Calculated MW||26017 Da|
|Antigen Region||198-227 aa|
|Other Names||Complement C1q subcomponent subunit A, C1QA|
|Target/Specificity||This C1QA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-227 amino acids from the C-terminal region of human C1QA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C1QA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.|
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Provided below are standard protocols that you may find useful for product applications.
C1QA is a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on hromosome 1.
Dardiotis,E., Koutsou,P. J. Neurol. Sci. (2009) In press
Martens,H.A., Zuurman,M.W. Ann. Rheum. Dis. 68 (5), 715-720 (2009)
Racila,E., Link,B.K. Clin. Cancer Res. 14 (20), 6697-6703 (2008)
Sjoberg,A.P., Nystrom,S. Mol. Immunol. 45 (11), 3213-3221 (2008)
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