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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   FGG Antibody (N-term)   

FGG Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - FGG Antibody (N-term) AP7325a
    FGG Antibody (N-term) (Cat. #AP7325a) western blot analysis in A431 cell line lysates (35ug/lane).This demonstrates the FGG antibody detected the FGG protein (arrow).
  • FC - FGG Antibody (N-term) AP7325a
    FGG Antibody (N-term) (Cat. #AP7325a) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • IF - FGG Antibody (N-term) AP7325a
    Confocal immunofluorescent analysis of FGG Antibody (N-term)(Cat#AP7325a) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02679
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51512 Da
Antigen Region 91-118 aa
Additional Information
Gene ID 2266
Other Names Fibrinogen gamma chain, FGG
Target/Specificity This FGG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-118 amino acids from the N-terminal region of human FGG.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFGG Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGG
Function Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Cellular Location Secreted.
Research Areas
Citations (0)

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FGG is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this protein lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.


Sie,M.P., Isaacs,A. J. Hypertens. 27 (7), 1392-1398 (2009)
Nowak-Gottl,U., Weiler,H. Blood (2009) In press
de Willige,S.U., Pyle,M.E. Thromb. Haemost. 101 (6), 1078-1084 (2009)
Yoshida,N., Imaoka,S. Thromb. Haemost. 68 (5), 534-538 (1992)

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$ 295.00
$ 99.00
Cat# AP7325a
(40 western blots)
Availability: In Stock
Bulk Size
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