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PTHLH Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - PTHLH Antibody (N-term) AP7336a
    Western blot analysis of lysates from HepG2 mouse NIH/3T3 cell line (from left to right), using PTHLH Antibody (N-term) (Cat. #AP7336a). AP7336a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
  • WB - PTHLH Antibody (N-term) AP7336a
    Western blot analysis of PTHLH Antibody (N-term) (Cat. #AP7336a) in mouse kidney tissue lysates (35ug/lane). PTHLH (arrow) was detected using the purified Pab.
  • IHC-P - PTHLH Antibody (N-term) AP7336a
    PTHLH Antibody (N-term) (Cat. #AP7336a) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PTHLH Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P12272
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 20194 Da
Antigen Region 10-41 aa
Additional Information
Gene ID 5744
Other Names Parathyroid hormone-related protein, PTH-rP, PTHrP, Parathyroid hormone-like protein, PLP, PTHrP[1-36], PTHrP[38-94], Osteostatin, PTHrP[107-139], PTHLH, PTHRP
Target/Specificity This PTHLH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-41 amino acids from the N-terminal region of human PTHLH.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPTHLH Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PTHRP
Function Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1- dependent manner through activation of Rac1.
Cellular Location Cytoplasm. Nucleus. Secreted.
Tissue Location Ubiquitous. Also expressed in the mammary gland
Research Areas
Citations ( 0 )


PTHLH is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy.


Trynka,G., Zhernakova,A. Gut 58 (8), 1078-1083 (2009) Nakao,A., Kajiya,H. J. Dent. Res. 88 (6), 551-556 (2009) Iwamura,M., Hellman,J. Urology 48 (2), 317-325 (1996) Fenton,A.J., Kemp,B.E. Endocrinology 129 (6), 3424-3426 (1991)

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Cat# AP7336a
(40 western blots)
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