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CP Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CP Antibody (Center) AP7340C
    Western blot analysis of CP Antibody (Center) (Cat. #AP7340c) in mouse lung tissue lysates (35ug/lane). CP (arrow) was detected using the purified Pab.
  • IHC-P - CP Antibody (Center) AP7340C
    CP Antibody (Center) (Cat. #AP7340c) IHC analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CP Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - CP Antibody (Center) AP7340C
    CP Antibody (Center) (Cat. #AP7340c) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P00450
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 122205 Da
Antigen Region 547-577 aa
Additional Information
Gene ID 1356
Other Names Ceruloplasmin, Ferroxidase, CP
Target/Specificity This CP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 547-577 amino acids from the Central region of human CP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CP
Function Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).
Cellular Location Secreted. Note=Colocalizes with GCP1 in secretory intracellular compartments.
Tissue Location Expressed by the liver and secreted in plasma.
Research Areas
Citations (0)

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CP is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this protein cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities.


Park,Y., Lee,I.S. Arch. Pharm. Res. 32 (5), 693-698 (2009)
Altamura,C., Squitti,R. Stroke 40 (4), 1282-1288 (2009)
Squitti,R., Quattrocchi,C.C. Prion 2 (1), 23-27 (2008)

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Cat# AP7340C
(40 western blots)
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