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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Tyrosinase Antibody (C-term)   

Tyrosinase Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Tyrosinase Antibody (C-term) AP7345B
    Western blot analysis of Tyrosinase antibody (C-term) (Cat. #AP7345b) in HepG2 cell line lysates (35ug/lane). Tyrosinase (arrow) was detected using the purified Pab.
  • IHC-P - Tyrosinase Antibody (C-term) AP7345B
    Tyrosinase Antibody (C-term) (AP7345b)immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Tyrosinase Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
  • IF - Tyrosinase Antibody (C-term) AP7345B
    Confocal immunofluorescent analysis of Tyrosinase Antibody (C-term)(Cat#AP7345b) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
  • FC - Tyrosinase Antibody (C-term) AP7345B
    Tyrosinase Antibody (C-term) (Cat. #AP7345b) flow cytometric analysis of A375 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P14679
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 60393 Da
Antigen Region 486-513 aa
Additional Information
Gene ID 7299
Other Names Tyrosinase, LB24-AB, Monophenol monooxygenase, SK29-AB, Tumor rejection antigen AB, TYR
Target/Specificity This Tyrosinase antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 486-513 amino acids from the C-terminal region of human Tyrosinase.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTyrosinase Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TYR
Function This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
Cellular Location Melanosome membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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TYR catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The protein has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this protein result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation.


Ostankovitch,M. J. Immunol. 182 (8), 4830-4835 (2009)
Chintamaneni,C.D. Proc. Natl. Acad. Sci. U.S.A. 88 (12), 5272-5276 (1991)

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Cat# AP7345B
(40 western blots)
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