|Application ||WB, FC, E|
|Calculated MW||10180 Da|
|Antigen Region||37-67 aa|
|Other Names||Protein S100-A6, Calcyclin, Growth factor-inducible protein 2A9, MLN 4, Prolactin receptor-associated protein, PRA, S100 calcium-binding protein A6, S100A6, CACY|
|Target/Specificity||This S100A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-67 amino acids from the C-terminal region of human S100A6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||S100A6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.|
|Cellular Location||Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
S100A6 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis.
van Dieck,J. J. Biol. Chem. 284 (20), 13804-13811 (2009)
Tsoporis,J.N., Izhar,S. J. Biol. Chem. 283 (44), 30174-30183 (2008)
Lee,Y.T., Dimitrova,Y.N. Biochemistry 47 (41), 10921-10932 (2008)
Melle,C., Ernst,G. PLoS ONE 3 (12), E3767 (2008)
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