|Application ||WB, IHC-P, FC, E|
|Calculated MW||129696 Da|
|Antigen Region||1094-1122 aa|
|Other Names||Tectonin beta-propeller repeat-containing protein 1, TECPR1, KIAA1358|
|Target/Specificity||This TECPR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1094-1122 amino acids from the C-terminal region of human TECPR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TECPR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.|
|Cellular Location||Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes|
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