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>   home   >   Products   >   Primary Antibodies   >   MEN1 Antibody (T594)   

MEN1 Antibody (T594)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MEN1 Antibody (T594) AP7415b
    Western blot analysis of anti-MEN1 Antibody (T594) (Cat.#AP7415b) in Ramos cell line lysates (35ug/lane). MEN1(arrow) was detected using the purified Pab.
  • IHC-P - MEN1 Antibody (T594) AP7415b
    Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with MEN1 Antibody (T594) (Cat.#AP7415b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • IF - MEN1 Antibody (T594) AP7415b
    Confocal immunofluorescent analysis of MEN1 Antibody (T594)(Cat#AP7415b) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O00255
Other Accession Q9WVR8, O88559, Q0P5I0, NP_000235
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 68023 Da
Antigen Region 584-615 aa
Additional Information
Gene ID 4221
Other Names Menin, MEN1, SCG2
Target/Specificity This MEN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 584-615 amino acids from human MEN1.
Dilution WB~~1:1000
IHC-P~~1:10~50
IF~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMEN1 Antibody (T594) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEN1
Synonyms SCG2
Function Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
Cellular Location Nucleus. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation
Tissue Location Ubiquitous.
Citations (0)

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Background

Menin (MEN1) is a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known.

References

Hashimoto,M., Int. J. Oncol. 33 (2), 333-340 (2008)
Vidal,A., J Eur Acad Dermatol Venereol 22 (7), 835-838 (2008)
Pieterman,C.R., Clin. Endocrinol. (Oxf) (2008)

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$ 295.00
$ 99.00
Cat# AP7415b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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