|Application ||WB, IHC-P, IF, E|
|Other Accession||Q9WVR8, O88559, Q0P5I0, NP_000235|
|Calculated MW||68023 Da|
|Antigen Region||584-615 aa|
|Other Names||Menin, MEN1, SCG2|
|Target/Specificity||This MEN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 584-615 amino acids from human MEN1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MEN1 Antibody (T594) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.|
|Cellular Location||Nucleus. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation|
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Provided below are standard protocols that you may find useful for product applications.
Menin (MEN1) is a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known.
Hashimoto,M., Int. J. Oncol. 33 (2), 333-340 (2008)
Vidal,A., J Eur Acad Dermatol Venereol 22 (7), 835-838 (2008)
Pieterman,C.R., Clin. Endocrinol. (Oxf) (2008)
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