|Application ||WB, IHC-P, FC, E|
|Calculated MW||89083 Da|
|Antigen Region||757-785 aa|
|Other Names||Conserved oligomeric Golgi complex subunit 4, COG complex subunit 4, Component of oligomeric Golgi complex 4, COG4|
|Target/Specificity||This COG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 757-785 amino acids from the C-terminal region of human COG4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COG4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.|
|Cellular Location||Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG4.
Whyte J.R., Munro S.Dev. Cell 1:527-537(2001)
Ota T., Suzuki Y., Nishikawa T.Nat. Genet. 36:40-45(2004)
Rikova K., Guo A., Zeng Q.Cell 131:1190-1203(2007)
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