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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ADAMTS13 Antibody (Center)   

ADAMTS13 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ADAMTS13 Antibody (Center) AP7438c
    Western blot analysis of anti-ADAMTS13 Antibody (Center)(Cat.#AP7438c) in CEM cell line lysates (35ug/lane). ADAMTS13 (arrow) was detected using the purified Pab.
  • IHC-P - ADAMTS13 Antibody (Center) AP7438c
    Formalin-fixed and paraffin-embedded human hepatocarcinoma with ADAMTS13 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q76LX8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 153604 Da
Antigen Region 829-858 aa
Additional Information
Gene ID 11093
Other Names A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8
Target/Specificity This ADAMTS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-858 amino acids from the Central region of human ADAMTS13.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsADAMTS13 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C9orf8
Function Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.
Cellular Location Secreted. Note=Secretion enhanced by O-fucosylation of TSP type-1 repeats
Tissue Location Plasma. Expressed primarily in liver.
Research Areas
Citations (0)

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ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.


Zheng X., Chung D., Takayama T.K.J. Biol. Chem. 276:41059-41063(2001)
Levy G.G., Nichols W.C.Nature 413:488-494(2001)
Cal S., Obaya A.J., Llamazares M., Garabaya C.Gene 283:49-62(2002)
Zheng X., Nishio K., Majerus E.M.J. Biol. Chem. 278:30136-30141(2003)
Anderson P.J., Kokame K., Sadler J.E.J. Biol. Chem. 281:850-857(2006)
Pimanda J.E., Maekawa A., Wind T.Blood 103:627-629(2004)
Plaimauer B., Fuhrmann J., Mohr G.Blood 107:118-125(2006)

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Cat# AP7438c
(40 western blots)
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