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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IGHM Antibody (N-term)   

IGHM Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - IGHM Antibody (N-term) AP7470a
    Western blot analysis of IGHM antibody (N-term) (Cat.#AP7470a) in T47D cell line lysates (35ug/lane). IGHM (arrow) was detected using the purified Pab.
  • IHC-P - IGHM Antibody (N-term) AP7470a
    Formalin-fixed and paraffin-embedded human breast carcinoma reacted with IGHM Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01871
Other Accession P04220
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 49307 Da
Antigen Region 103-131 aa
Additional Information
Other Names Ig mu chain C region, IGHM
Target/Specificity This IGHM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-131 amino acids from the N-terminal region of human IGHM.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIGHM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts.
Cellular Location Isoform 1: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM
Research Areas
Citations (0)

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Dorai H., Gillies S.D.Nucleic Acids Res. 17:6412-6412(1989)
Rabbitts T.H.Nucleic Acids Res. 9:4509-4524(1981)
Watanabe S.Hoppe-Seyler's Z. Physiol. Chem. 354:1505-1509(1973)

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Cat# AP7470a
(40 western blots)
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