|Application ||WB, IHC-P, E|
|Calculated MW||25406 Da|
|Antigen Region||2-31 aa|
|Other Names||Ornithine decarboxylase antizyme 1, ODC-Az, OAZ1, OAZ|
|Target/Specificity||This OAZ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-31 amino acids from the N-terminal region of human OAZ1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OAZ1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to and targeting ODC1 for degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.|
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Provided below are standard protocols that you may find useful for product applications.
OAZ1 catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. This protein play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein expression is auto-regulated by polyamine-enhanced translational frameshifting.
Grimwood J., Gordon L.A.Nature 428:529-535(2004)
Hayashi T., Matsufuji S.Gene 203:131-139(1997)
Tewari D.S., Qian Y.Biochim. Biophys. Acta 1209:293-295(1994)
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