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OAZ1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - OAZ1 Antibody (N-term) AP7477A
    Western blot analysis of OAZ1 Antibody (N-term) (Cat.#AP7477a) in mouse heart tissue lysates (35ug/lane). OAZ1 (arrow) was detected using the purified Pab.
  • IHC-P - OAZ1 Antibody (N-term) AP7477A
    Formalin-fixed and paraffin-embedded mouse heart tissue reacted with OAZ1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P54368
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 25406 Da
Antigen Region 2-31 aa
Additional Information
Gene ID 4946
Other Names Ornithine decarboxylase antizyme 1, ODC-Az, OAZ1, OAZ
Target/Specificity This OAZ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-31 amino acids from the N-terminal region of human OAZ1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsOAZ1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OAZ1
Synonyms OAZ
Function Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to and targeting ODC1 for degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
Research Areas
Citations (0)

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OAZ1 catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. This protein play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein expression is auto-regulated by polyamine-enhanced translational frameshifting.


Grimwood J., Gordon L.A.Nature 428:529-535(2004)
Hayashi T., Matsufuji S.Gene 203:131-139(1997)
Tewari D.S., Qian Y.Biochim. Biophys. Acta 1209:293-295(1994)

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Cat# AP7477A
(40 western blots)
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