|Application ||WB, IHC-P, FC, E|
|Calculated MW||66035 Da|
|Antigen Region||308-335 aa|
|Other Names||Insulin-like growth factor-binding protein complex acid labile subunit, ALS, IGFALS, ALS|
|Target/Specificity||This IGFALS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-335 amino acids from the Central region of human IGFALS.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||IGFALS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.|
|Cellular Location||Secreted, extracellular space.|
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Provided below are standard protocols that you may find useful for product applications.
IGFALS is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this protein are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty.
Leong S.R., Baxter R.C.Mol. Endocrinol. 6:870-876(1992)
Suwanichkul A.Endocrinology 141:833-838(2000)
Liu T., Qian W.-J.J. Proteome Res. 4:2070-2080(2005)
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