|Application ||WB, IF, FC, E|
|Calculated MW||32923 Da|
|Antigen Region||1-30 aa|
|Other Names||F-actin-capping protein subunit alpha-1, CapZ alpha-1, CAPZA1|
|Target/Specificity||This CAPZA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CAPZA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CAPZA1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|
|Cellular Location||Cytoplasm, cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
CAPZA1 is a member of the F-actin capping protein alpha subunit family. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments.
Maun,N.A., Speicher,D.W. Biochemistry 35 (11), 3518-3524 (1996)
Barron-Casella,E.A., Torres,M.A. J. Biol. Chem. 270 (37), 21472-21479 (1995)
Canton,D.A., Olsten,M.E. J. Biol. Chem. 281 (47), 36347-36359 (2006)
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