- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Calculated MW||53157 Da|
|Antigen Region||7-38 aa|
|Other Names||Gastric inhibitory polypeptide receptor, GIP-R, Glucose-dependent insulinotropic polypeptide receptor, GIPR|
|Target/Specificity||This GIPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-38 amino acids from the N-terminal region of human GIPR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GIPR Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
Provided below are standard protocols that you may find useful for product applications.
GIPR also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. This protein was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. The protein is involved in several other facets of the anabolic response.
Herbach,N. Am. J. Physiol. Renal Physiol. 296 (4), F819-F829 (2009) Rudovich,N., Kaiser,S. Regul. Pept. 142 (3), 138-145 (2007) Nitz,I., Fisher,E. Mol Nutr Food Res 51 (8), 1046-1052 (2007)
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