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Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O00311 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit Ig |
| Calculated MW | 63888 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 8317 |
|---|---|
| Other Names | Cell division cycle 7-related protein kinase, CDC7-related kinase, HsCdc7, huCdc7, CDC7, CDC7L1 |
| Target/Specificity | This CDC7 (CDC7L1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CDC7 (CDC7L1). |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CDC7 (CDC7L1) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDC7 |
|---|---|
| Synonyms | CDC7L1 |
| Function | Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CDC7L1 is predominantly localized in the nucleus and is a cell division cycle protein with kinase activity. Although expression levels of the protein appear to be constant throughout the cell cycle, the protein kinase activity appears to increase during S phase. It has been suggested that the protein is essential for initiation of DNA replication and that it plays a role in regulating cell cycle progression. Overexpression of this gene product may be associated with neoplastic transformation for some tumors.
References
Montagnoli, A., et al., EMBO J. 21(12):3171-3181 (2002).
Hess, G.F., et al., Gene 211(1):133-140 (1998).
Jiang, W., et al., Proc. Natl. Acad. Sci. U.S.A. 94(26):14320-14325 (1997).
Sato, N., et al., EMBO J. 16(14):4340-4351 (1997).
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